Best Testosterone Boosters for Men with Kidney Disease: CKD-Safe Options Reviewed (2026)

Testosterone deficiency affects an estimated 27% to 66% of men with chronic kidney disease — a prevalence that far exceeds what is observed in the general male population. As CKD progresses and glomerular filtration rate (GFR) declines, testosterone levels fall in parallel, driven by the uremic disruption of the hypothalamic-pituitary-gonadal (HPG) axis, chronic inflammation, nutritional depletion, and the effects of commonly prescribed renal medications.

The clinical consequences extend well beyond low libido. In the CKD population, testosterone deficiency is independently associated with accelerated sarcopenia and protein-energy wasting, erythropoiesis-stimulating agent (ESA) hyporesponsiveness, decreased bone mineral density contributing to CKD-mineral bone disorder, increased cardiovascular morbidity, and higher all-cause mortality. Published cohort data from the NHANES database and the EVOLVE trial confirm that men with CKD and low testosterone have significantly worse survival outcomes compared to those with normal levels.

For a comprehensive overview of why standard testosterone replacement therapy (TRT) requires special caution in kidney disease — including the risks of fluid retention, hypertension exacerbation, and potential renal tubular injury — our education team has published a detailed companion guide: Testosterone and Kidney Disease: Natural TRT Alternatives for Men with CKD. That resource covers the mechanisms of CKD-related hypogonadism, the clinical consensus on TRT in renal patients, and foundational lifestyle strategies for testosterone support.

This article builds on that foundation by providing an expanded evaluation of the top testosterone-boosting supplements currently available — assessed specifically through the lens of ingredient safety, CKD-relevant mechanisms, drug interactions, and electrolyte considerations that matter for men managing kidney disease.

Important medical disclaimer: This article is for educational purposes only and does not constitute medical advice. Men with chronic kidney disease should never begin any supplementation without consulting their nephrologist. Testosterone management in CKD requires monitoring of fluid status, blood pressure, hematocrit, PSA, potassium, phosphorus, and renal function markers. Many common CKD medications — including ACE inhibitors, ARBs, statins, spironolactone, calcimimetics, and opioid pain medications — independently affect testosterone levels. None of the supplements discussed in this article are FDA-approved treatments for hypogonadism or chronic kidney disease.

How Our Nephrology Education Team Evaluated These Supplements

The testosterone booster market is saturated with products marketed to the general male population — and the overwhelming majority of these products make no attempt to address the unique safety and efficacy considerations relevant to men with compromised kidney function. Our education team assessed each supplement using criteria specifically calibrated for the CKD population.

Ingredient safety in renal impairment: We evaluated each formula for ingredients that may affect potassium levels, phosphorus load, or fluid balance — all critical parameters in CKD management. We also assessed for ingredients with published case reports of nephrotoxicity or acute kidney injury.

Drug interaction potential: CKD patients typically manage complex medication regimens. We flagged ingredients with known or suspected interactions with antihypertensives, anticoagulants, phosphate binders, ESAs, and diabetes medications.

Clinical evidence base: We prioritized supplements containing ingredients with published human clinical trial data supporting testosterone-related outcomes — particularly D-Aspartic Acid, KSM-66 Ashwagandha, fenugreek, zinc, and vitamin D, all of which have documented research in peer-reviewed journals.

Manufacturing standards: Given that CKD patients are medically vulnerable, we required products manufactured in FDA-registered, cGMP-certified facilities with transparent ingredient sourcing.

Practical considerations: Pill burden, dosing complexity, and format (capsule vs. powder vs. gummy) matter for CKD patients who may already take 10 or more daily medications.

The 7 Testosterone Boosters We Reviewed

• Testosil — Strongest clinical evidence base (adaptogenic + LH support)
• Red Boost — Best nitric oxide and circulatory focus (powder format)
• TestoGen — Best for SHBG reduction and free testosterone optimization
• TestoPrime — Best multi-pathway adaptogenic formula
• TestoDren — Simplest formula (single active ingredient)
• Testo Lab Pro — Best for cortisol management and estrogen control
• Alpha Tonic — Best bioavailable powder with broad ingredient profile

Testosil — Strongest Clinical Evidence Base

• Format: Capsules (120 per bottle, 30-day supply)
• Serving: 4 capsules daily with water
• Key Ingredients: KSM-66 Ashwagandha, D-Aspartic Acid, ZMA (Zinc, Magnesium, B6), Fenugreek, L-Arginine HCL, Panax Ginseng, Allium Sativa, AstraGin
• Manufacturing: cGMP-certified facility
• Refund: Lifetime money-back guarantee ([email protected])

Clinical Assessment

Testosil leads our evaluation based on the strength of its clinical evidence. The formulation is anchored by KSM-66, a standardized ashwagandha extract with published randomized controlled trial data demonstrating cortisol reductions of approximately 27.9% over eight weeks and testosterone improvements when combined with exercise. For CKD patients, cortisol reduction is particularly relevant — chronic kidney disease is characterized by sustained HPA axis activation that further suppresses testosterone through a compounding feedback loop.

The ZMA complex addresses three nutrients — zinc, magnesium, and vitamin B6 — that are frequently depleted in CKD patients through a combination of dietary restrictions, dialysate losses, and medication interactions. Published data confirms that zinc deficiency alone can significantly impair testosterone biosynthesis. D-Aspartic Acid supports luteinizing hormone (LH) release, targeting the secondary hypogonadism (impaired hypothalamic-pituitary signaling) that characterizes CKD-related testosterone decline.

Clinical trials cited by the manufacturer report a 5.67% increase in VO2 max over 12 weeks — a finding relevant to the exercise intolerance commonly experienced by CKD patients.

As discussed in our companion TRT alternatives guide, the cortisol-testosterone relationship is amplified in kidney disease, making adaptogenic approaches like ashwagandha particularly relevant for this population.

CKD-Specific Considerations

Magnesium monitoring required: The kidneys are the primary excretory route for magnesium. Patients with GFR below 30 mL/min may accumulate magnesium, potentially causing hypermagnesemia. Serum magnesium should be monitored if supplementing. L-Arginine may affect blood pressure — discuss with your nephrology team if you are on antihypertensive medications, as additive hypotensive effects are possible. Ashwagandha has limited published safety data specifically in CKD populations; standard doses appear well-tolerated in the general population, but CKD-specific clearance data is not yet available. Zinc may interact with phosphate binders and iron supplements commonly prescribed in CKD.

Red Boost — Best Nitric Oxide and Circulatory Focus

• Format: Powder (121g per container, ~30-day supply)
• Serving: 1 scoop (~4.13g) daily mixed with water or beverage
• Key Ingredients: Fenugreek, Horny Goat Weed (Icariin), Tongkat Ali Extract, Citrulline, Beetroot Powder
• Manufacturing: FDA-registered facility, GMP-certified, non-GMO, gluten-free
• Refund: 180-day money-back guarantee ([email protected])

Clinical Assessment

Red Boost takes a cardiovascular and circulatory approach to testosterone support — an angle with particular relevance given that cardiovascular disease is the leading cause of mortality in CKD patients. The formula targets nitric oxide production and blood flow, which intersects with both testosterone support and the endothelial dysfunction that characterizes advanced kidney disease.

Fenugreek has published clinical data demonstrating reductions in sex hormone-binding globulin (SHBG), which increases the proportion of bioavailable free testosterone — a mechanism that is especially relevant in CKD because SHBG alterations are common in this population. Citrulline is a nitric oxide precursor that supports endothelial function and may benefit the cardiovascular profile of CKD patients. Beetroot powder provides dietary nitrates that support blood pressure management and exercise capacity, both of which are relevant CKD concerns.

Icariin (from horny goat weed) has demonstrated PDE5 inhibitory activity in published studies, potentially supporting vascular function. The powder format allows for dose flexibility and avoids adding to the capsule burden that CKD patients already manage.

CKD-Specific Considerations

Critical — Tongkat Ali safety alert for CKD: A case report presented at the American Society of Nephrology's Kidney Week documented a previously healthy man who developed acute interstitial nephritis (AKI, creatinine 4.06 mg/dL) while taking herbal supplements including Tongkat Ali extract, Mucuna extract, and maca. Kidney biopsy confirmed allergic interstitial nephritis. While isolated Tongkat Ali has shown nephroprotective properties in preclinical rat models, published clinical reviews advise that individuals with kidney disease should exercise particular caution or avoid Tongkat Ali. This is a significant consideration for CKD patients evaluating this product — discuss with your nephrologist before use.

Beetroot is high in potassium — a critical concern for CKD patients on potassium-restricted diets or those with hyperkalemia risk. Patients with GFR below 30 mL/min should verify potassium content with their care team. Horny goat weed may interact with blood thinners and has limited renal safety data. Citrulline is generally well-tolerated but its conversion to arginine means the same blood pressure considerations apply as with direct L-arginine supplementation.

TestoGen — Best for SHBG Reduction and Free Testosterone

• Format: Capsules (120 per bottle, 30-day supply)
• Serving: 4 capsules daily with water before breakfast
• Key Ingredients: D-Aspartic Acid, Fenugreek Extract, Vitamin D3, Zinc, Nettle Leaf Extract, Boron, Korean Red Ginseng
• Manufacturing: FDA-registered facility, GMP-certified, free of synthetics, GMOs, gluten, soy, dairy, caffeine
• Refund: 100-day money-back guarantee ([email protected])

Clinical Assessment

TestoGen addresses testosterone optimization through a dual mechanism that is particularly well-matched to CKD-related hypogonadism: stimulating LH-driven testosterone production (via D-Aspartic Acid) while simultaneously reducing SHBG binding (via nettle leaf extract and boron) to increase free, biologically active testosterone.

This dual approach matters for CKD patients because the diagnosis of hypogonadism in this population is complicated by SHBG alterations. Total testosterone measurements can be misleading when SHBG is abnormally low (as in obesity, diabetes, and nephrotic syndrome) or high (as in aging). The Endocrine Society specifically recommends free testosterone measurement in CKD patients where SHBG alterations are suspected. By targeting SHBG reduction alongside testosterone production, TestoGen addresses both sides of the equation.

Vitamin D3 is relevant because vitamin D deficiency is nearly universal in advanced CKD and is directly correlated with lower testosterone levels. However, as our TRT alternatives guide explains, CKD disrupts vitamin D metabolism because impaired renal hydroxylation limits conversion to the active 1,25-dihydroxyvitamin D form. Boron has published data showing increases in free testosterone and reductions in estradiol — its mechanism of preventing testosterone-to-estrogen conversion aligns with TestoGen's overall free-testosterone-maximization strategy.

The caffeine-free formulation is notable — many CKD patients have caffeine restrictions, and this eliminates that concern entirely.

CKD-Specific Considerations

Vitamin D supplementation in CKD requires medical supervision. Standard D3 may be insufficient because the kidneys cannot adequately convert it to the active form. CKD patients may need calcitriol or paricalcitol instead — discuss your current vitamin D management with your nephrologist before adding supplemental D3. Nettle leaf has diuretic properties that could affect fluid balance and electrolyte levels in CKD patients. Zinc interactions with phosphate binders and iron supplements should be reviewed. Korean Red Ginseng may affect blood sugar levels — relevant for the approximately 40% of CKD patients with concurrent diabetes. The 4-capsule daily regimen adds to pill burden.

TestoPrime — Best Multi-Pathway Adaptogenic Formula

• Format: Capsules (120 per bottle, 30-day supply)
• Serving: 4 capsules daily before breakfast
• Key Ingredients: D-Aspartic Acid, Panax Ginseng, KSM-66 Ashwagandha, Fenugreek, Green Tea Extract, Pomegranate Extract, Zinc, Vitamin D, B Vitamins, Garlic Extract, Black Pepper Extract (Piperine)
• Manufacturing: GMP-certified facilities (USA and UK), non-GMO, soy-free, vegan-friendly
• Refund: Lifetime money-back guarantee ([email protected])

Clinical Assessment

TestoPrime takes the broadest multi-pathway approach of any supplement in this evaluation, combining adaptogenic herbs (ashwagandha, ginseng), LH-stimulating compounds (D-Aspartic Acid), SHBG-modulating ingredients (fenugreek), antioxidants (pomegranate, green tea), and essential micronutrients (zinc, vitamin D, B vitamins). For CKD patients, the antioxidant component deserves particular attention — oxidative stress is a hallmark of chronic kidney disease, contributing to endothelial dysfunction, cardiovascular complications, and accelerated cellular aging across organ systems.

Pomegranate extract has published research specifically relevant to cardiovascular and antioxidant outcomes. Green tea catechins provide documented anti-inflammatory activity. Black pepper extract (piperine) enhances bioavailability of the other ingredients — a practical benefit for CKD patients whose gastrointestinal absorption may be compromised by uremia-related gut dysfunction.

The combination of ashwagandha and ginseng provides dual adaptogenic support, addressing the chronic physiological stress that characterizes CKD and the resulting cortisol elevation that compounds testosterone suppression.

CKD-Specific Considerations

Green tea extract contains caffeine — discuss with your care team if caffeine intake is restricted. Vitamin D in CKD requires the same medical supervision noted for TestoGen above. Garlic extract may have mild blood-thinning properties — relevant for patients on anticoagulants. Piperine can alter the absorption and metabolism of numerous medications by inhibiting hepatic CYP3A4 and P-glycoprotein — this is a significant consideration for CKD patients on complex medication regimens and should be reviewed with your pharmacist or nephrologist. Fenugreek can affect blood glucose levels — important for CKD patients with concurrent diabetes.

TestoDren — Simplest Formula (Single Active Ingredient)

• Format: Capsules (30 per bottle, 30-day supply)
• Serving: 1 capsule daily with breakfast
• Key Ingredient: Furosap (proprietary fenugreek seed extract, Trigonella foenum-graecum)
• Manufacturing: cGMP-compliant facility (USA), gluten-free, soy-free
• Refund: 67-day money-back guarantee ([email protected])

Clinical Assessment

TestoDren represents a fundamentally different approach: a single-ingredient formula containing only Furosap, a patented fenugreek seed extract. The manufacturer cites clinical data showing increases in free testosterone levels of up to 72.87%.

From a nephrology education perspective, the single-ingredient approach has a distinct advantage for CKD patients — simplicity reduces risk. When managing a complex chronic condition with multiple medications, fewer supplement ingredients mean fewer potential interactions to evaluate, fewer electrolyte variables to monitor, and a clearer cause-and-effect relationship if adverse effects occur. If something goes wrong with a 12-ingredient supplement, identifying the culprit is far more difficult than with a single-compound formula.

Fenugreek has published clinical data supporting its role in increasing free testosterone through SHBG reduction and inhibition of enzymes that convert testosterone to estrogen (aromatase). The furostanolic saponins in fenugreek are the active compounds responsible for these effects.

The once-daily, single-capsule serving is the lowest pill burden of any product in this evaluation — a meaningful practical advantage for CKD patients already managing extensive medication schedules.

CKD-Specific Considerations

Fenugreek can lower blood glucose — critical monitoring point for CKD patients with concurrent diabetes, particularly those on insulin or sulfonylureas where additive hypoglycemia is possible. Fenugreek may have mild diuretic properties — discuss fluid balance implications with your care team. The shorter 67-day refund window is less generous than competitors offering 180-day or lifetime guarantees, which provides less time to assess effectiveness. The single-ingredient approach means this product does not address the micronutrient deficiencies (zinc, vitamin D, magnesium) that are common contributors to CKD-related testosterone decline — those would need to be addressed separately under medical supervision.

Testo Lab Pro — Best for Cortisol Management and Estrogen Control

• Format: Capsules (90 per bottle, 30-day supply)
• Serving: 3 capsules daily with water before breakfast
• Key Ingredients: Ashwagandha Root Extract, Mucuna Pruriens, D-Aspartic Acid, Luteolin, Zinc, Magnesium, Vitamin D3, Boron
• Manufacturing: cGMP-certified, vegan-friendly, non-GMO, soy-free, stimulant-free, prebiotic fiber capsules
• Refund: 30-day money-back guarantee ([email protected])

Clinical Assessment

Testo Lab Pro targets testosterone optimization through a three-pronged hormonal strategy: increasing production (D-Aspartic Acid, zinc, vitamin D), reducing cortisol-mediated suppression (ashwagandha), and preventing testosterone-to-estrogen conversion (luteolin). The inclusion of luteolin as an aromatase inhibitor is distinctive — most testosterone boosters rely solely on fenugreek for anti-estrogenic effects, while luteolin operates through a different mechanism (direct flavonoid-based aromatase inhibition).

Mucuna pruriens provides L-DOPA, a dopamine precursor. Dopamine has a documented role in regulating pituitary LH secretion, and elevated prolactin (which suppresses testosterone) is a recognized complication of CKD. By supporting dopaminergic pathways, Mucuna pruriens may help address the hyperprolactinemia that contributes to CKD-related hypogonadism.

The prebiotic fiber capsule formulation is a thoughtful manufacturing detail — CKD patients frequently experience gastrointestinal symptoms, and prebiotic support may improve both tolerability and nutrient absorption. The stimulant-free, vegan-friendly profile minimizes additional dietary restriction concerns.

CKD-Specific Considerations

Critical — Mucuna pruriens safety alert for CKD: The same ASN Kidney Week case report that flagged Tongkat Ali also involved concurrent Mucuna extract use in a patient who developed acute interstitial nephritis. While Mucuna pruriens was not isolated as the sole cause, its inclusion in the implicated supplement combination warrants caution for CKD patients. Additionally, Mucuna pruriens' L-DOPA content can interact with dopaminergic medications and MAO inhibitors. Magnesium monitoring is required as noted for Testosil above — accumulation risk in reduced GFR. Vitamin D requires the same CKD-specific medical supervision. The 30-day refund window is the shortest in this evaluation — the manufacturer's recommended assessment period may not align with realistic timelines for CKD patients to evaluate effectiveness under medical supervision. Boron is primarily excreted renally; limited data exists on boron accumulation in CKD.

Alpha Tonic — Best Bioavailable Powder with Broad Ingredient Profile

• Format: Powder (30 servings per jar)
• Serving: 1 scoop daily mixed with water or beverage
• Key Ingredients: Ashwagandha, Tongkat Ali, Boron, Maca Root, Panax Ginseng, Fenugreek, Nettle Root, Vitamin D, Artichoke Extract
• Manufacturing: 100% natural, vegan-friendly, non-GMO, stimulant-free, non-habit forming
• Refund: 180-day money-back guarantee ([email protected])

Clinical Assessment

Alpha Tonic offers the broadest ingredient profile in powder format, combining adaptogenic herbs (ashwagandha, ginseng), testosterone-supportive botanicals (Tongkat Ali, fenugreek, maca), hormone modulators (nettle root, boron), and digestive support (artichoke extract). The bioavailable powder form may offer absorption advantages over capsule formats, particularly for CKD patients whose gastrointestinal function is compromised by uremia.

Nettle root's mechanism of SHBG binding — reducing the protein that sequesters free testosterone — complements fenugreek's aromatase inhibition, creating a dual free-testosterone optimization pathway. Maca root has published research demonstrating improvements in libido and sexual function through neurochemical pathways independent of direct testosterone elevation — relevant for CKD patients whose sexual dysfunction often has multiple contributing factors beyond hormonal status alone.

Artichoke extract is an interesting inclusion for CKD patients — published data suggests hepatoprotective and lipid-lowering properties, and CKD patients frequently manage dyslipidemia as a cardiovascular risk factor.

CKD-Specific Considerations

Tongkat Ali — same safety alert applies as noted for Red Boost. The ASN Kidney Week case report of acute interstitial nephritis in a patient using Tongkat Ali-containing supplements, combined with published clinical reviews advising that individuals with kidney disease exercise caution, makes this a significant consideration. Discuss with your nephrologist. Nettle root has diuretic properties that may affect fluid and electrolyte balance. Maca root was also involved in the ASN nephritis case report (alongside Tongkat Ali and Mucuna) — while not isolated as the sole cause, its presence in the implicated combination warrants awareness. Boron accumulation concerns in reduced GFR as noted above. Vitamin D requires CKD-specific medical supervision. The broad ingredient profile means more potential interactions to evaluate with your pharmacy and nephrology team.

Ingredient Science: What the Published Research Shows

Understanding the evidence behind common testosterone-boosting ingredients helps CKD patients and their care teams make informed decisions. The following compounds appear across multiple products in this evaluation and have published human clinical data.

D-Aspartic Acid stimulates pituitary release of luteinizing hormone, which signals the testes to increase testosterone production. Published trials have demonstrated measurable testosterone increases within 12 days of supplementation. For CKD patients, this LH-stimulation mechanism is relevant because secondary hypogonadism (impaired pituitary-gonadal signaling) is a primary driver of testosterone decline in kidney disease.

Fenugreek contains furostanolic saponins that increase free testosterone through two mechanisms: reducing SHBG-bound testosterone and inhibiting aromatase enzymes that convert testosterone to estrogen. Clinical studies have demonstrated improvements in libido, strength, and free testosterone levels. The SHBG-reduction pathway is particularly relevant for CKD, where SHBG alterations complicate testosterone assessment and management.

Ashwagandha (KSM-66) is an adaptogen with published RCT data showing cortisol reductions of approximately 27.9% and significant testosterone improvements. Its mechanism operates upstream of direct testosterone production — by reducing cortisol-mediated HPG axis suppression. As discussed in our TRT alternatives guide, this cortisol-testosterone relationship is amplified in the CKD population.

Zinc is an essential cofactor in testosterone biosynthesis, and deficiency is directly linked to hypogonadism. Published research confirms that zinc supplementation can restore testosterone levels in deficient men. CKD patients are at elevated risk of zinc depletion through dietary restrictions, dialysate losses, and medication interactions — making zinc status assessment one of the most actionable interventions available.

Vitamin D has published data correlating sufficient levels with higher testosterone in male populations. Deficiency is nearly universal in advanced CKD. However, the kidney's role in activating vitamin D (converting 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D via renal 1α-hydroxylase) means that standard D3 supplementation may not achieve the desired hormonal effects in CKD patients. Active vitamin D forms (calcitriol, paricalcitol) prescribed by nephrology teams address this limitation.

Who Should Not Use Testosterone-Boosting Supplements

This guidance applies to all men but carries additional weight for the CKD population:

Men with unmonitored kidney disease: If you have not had a recent GFR assessment, serum electrolyte panel, and medication review with your nephrologist, introducing any new supplement carries undefined risk. Establish your baseline first.

Men with hyperkalemia or potassium-restricted diets: Several products in this evaluation contain beetroot powder, which is high in potassium. Even products without direct potassium-containing ingredients may affect electrolyte balance through diuretic effects or metabolic pathways.

Men on complex anticoagulation regimens: Ingredients including ginkgo biloba, garlic extract, horny goat weed, and dong quai may affect platelet function and interact with blood thinners.

Men with a history of prostate cancer: Published guidelines recommend against testosterone supplementation — whether pharmaceutical or natural — in men with active or prior prostate malignancy.

Men under 18 or women: These products are formulated for adult males and are not appropriate for other populations.

Men currently on prescription TRT: Combining natural testosterone boosters with pharmaceutical TRT without medical supervision risks erythrocytosis, cardiovascular complications, and hormonal imbalances.

Men with uncontrolled hypertension or heart failure: Ingredients that affect blood pressure, fluid balance, or nitric oxide production require careful evaluation in patients with cardiovascular comorbidities — which represent the majority of CKD patients.

Final Assessment from Our Education Team

Testosterone deficiency in chronic kidney disease is a clinically significant condition that affects quality of life, physical function, cardiovascular health, and survival. The products evaluated in this guide contain ingredients with varying levels of published evidence for testosterone support — but none of them are designed specifically for the CKD population, and each requires individual assessment for safety within the context of your kidney disease stage, medication regimen, and overall clinical picture.

These testosterone boosters may offer supportive benefits when used as one component of a comprehensive, medically supervised approach. The most evidence-supported ingredients across these products — zinc, vitamin D, ashwagandha, D-Aspartic Acid, and fenugreek — have documented mechanisms relevant to CKD-related hypogonadism. However, several ingredients present in these formulations carry specific cautions for kidney disease patients, including potassium-containing compounds, nephrotoxicity case reports (Tongkat Ali, Mucuna pruriens), drug interaction potential (piperine, nettle root), and electrolyte accumulation risks (magnesium, boron).

The essential first step remains the same: discuss testosterone testing with your nephrologist. Request morning total testosterone, free testosterone, LH, FSH, and SHBG measurements. Review your medication list for agents that may be contributing to testosterone suppression. Address correctable nutritional deficiencies under medical supervision. Then — and only then — evaluate whether supplementation is appropriate for your specific situation.

For additional guidance on the mechanisms of CKD-related testosterone decline, why standard TRT requires caution in kidney disease, and foundational lifestyle strategies for hormonal support, see our comprehensive companion guide: Testosterone and Kidney Disease: Natural TRT Alternatives for Men with CKD.

This article was researched and prepared by the nephrology education team at KidneyDiseaseMS.com using published clinical literature from peer-reviewed nephrology, endocrinology, and urology journals, including data presented at the American Society of Nephrology Kidney Week and published in the American Journal of Kidney Diseases, Nephrology Dialysis Transplantation, World Journal of Men's Health, and Clinical Journal of the American Society of Nephrology. This content is for educational purposes only and does not constitute medical advice. Chronic kidney disease and testosterone deficiency are complex medical conditions requiring individualized professional management. Always consult your nephrologist, endocrinologist, or primary care provider before making changes to your health regimen. Last updated: February 2026.